Posted by Jimmyboy on November 28, 2008, at 16:29:31
In reply to Re: Great comment on Opioids » Jay_Bravest_Face, posted by Sigismund on November 28, 2008, at 13:30:18
Interesting article on mu-opiod receptors and response to anti-depressants..
http://www.psychiatrictimes.com/display/article/10168/1153657?pageNumber=2
Summary
"Substantial evidence in rodents exists to support the role of the µ-opioid system in antidepressant response and the pathophysiology of depressive-like symptoms. In humans, the placebo effect is clearly mediated by the µ-opioid system, which potentially explains a portion of the response seen with many pharmaceuticals. Furthermore, the present data also suggest a role in antidepressant response and tolerance, as well as remission from major depression in humans. The interindividual differences in variations in the OPRM1 gene, and the associations described above, have implications in personalized medicine. One could imagine selecting one antidepressant over another based on genotypic constitution, and predictability of response rate, tolerance to the particular medication. Together this body of literature points to a new direction for research into novel antidepressant treatments and the pathology of MDD."
poster:Jimmyboy
thread:865440
URL: http://www.dr-bob.org/babble/20081123/msgs/865635.html