Posted by desolationrower on December 2, 2008, at 19:28:35
In reply to Re: Interrressting Concerta ER question and dosing :) » Jakeo29, posted by Phillipa on December 2, 2008, at 12:24:04
I've hear that before, that stimulants help people sleep. Can help with restless limb. There was a study of sleep in people taking them, and after a few months, sleep quality improved for the stimulant takers. Maybe you would be helped by a DA agonist? THey dohn't work for adhd, but often make patients drowsy and help with rls. That would probably seem more conventional to your doc than taking a stiulant. maybe some selegiline or bupropion would be a good idea too.
heres a start
Dopaminergic Control of SleepWake States
Dopamine depletion is involved in the pathophysiology of Parkinson's disease, whereas hyperdopaminergia may play a fundamental role in generating endophenotypes associated with schizophrenia. Sleep disturbances are known to occur in both schizophrenia and Parkinson's disease, suggesting that dopamine plays a role in regulating the sleepwake cycle. Here, we show that novelty-exposed hyperdopaminergic mice enter a novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological activity observed during rapid-eye-movement (REM) sleep. Treatment with haloperidol, a D2 dopamine receptor antagonist, reduces this abnormal intrusion of REM-like activity during wakefulness. Conversely, mice acutely depleted of dopamine enter a different novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological activity observed during slow-wave sleep (SWS). This dopamine-depleted state is marked by an apparent suppression of SWS and a complete suppression of REM sleep. Treatment with D2 (but not D1) dopamine receptor agonists recovers REM sleep in these mice. Altogether, these results indicate that dopamine regulates the generation of sleepwake states. We propose that psychosis and the sleep disturbances experienced by Parkinsonian patients result from dopamine-mediated disturbances of REM sleep.
-d/r
poster:desolationrower
thread:866242
URL: http://www.dr-bob.org/babble/20081123/msgs/866323.html