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Treatment Resistant (Refractory) Depression

Posted by CaptainAmerica1967 on December 12, 2008, at 5:24:21

In reply to I REALLY need some help guys..., posted by streetsk8er794 on December 12, 2008, at 0:02:57

Some of your wording that I noticed....

-"Anyways, I am now a completely different person with no ambition, no care about anything, and a different outlook on life."

-"Remember my love for music and dream of becoming a professional musician? I havent even attempted to write lyrics since I started Nardil. I actually have no dreams or aspirations anymore. I dont care about going to NA meetings, I dont want to practice guitar, going back to college is the last thing I'd ever do, I dont get horny so obviously I need no girlfriend, I spend money recklessly (as where before I was saving every dime I could to pay back my court fees and buy a car)."

-"I live with my parents and dont care about saving for a car (they give me rides anyways right?), I have a mediocre job that doesnt pay much, and I dont want college, so at this rate, I'll be a loser forever. I hang around drugs all the time now, and it doesnt bother me even a bit. Sh*t, I help em get higher. If I keep this up, I'll soon get high with em', and might as well say bye to my life as I know it. I just dont give a F*CK about anything. I'm crying as I'm writing this."

Sounds to me like you still have depression based upon the above quotes. Have your every tried Parnate instead of Nardil?

Parnate is chemically or structurally very similar to amphetamine and influences dopamine more so in theory would help sex drive more than Nardil. I was on Nardil for over fifteen years as I suffer from treatment resistant depression and have severe anxiety as well. Nardil stopped working as well as it had for me with the formula change in 2003-2004. Tried several years of Cymbalta, eventually went to Parnate.

Nardil tends to cause more sedation, more postural hypotension/dizziness, and orgasmic dysfunction than Parnate although Parnate may not be quite as effective for social anxiety as it doesn't affect GABA (gamma aminobutyric acid or benzodiazepines receptor activity) like Nardil does, but your taking Klonopin-clonazepam anyway so your getting the GABA affect. Xanax-alprazolam is usually superior to Klonopin for panic/anxiety and has antidepressant effects as well.

A book called The Anxiety Disease by David Sheehan, M.D., Director of Reasearch of the College of Medicine at the University of South Florida in Tampa, might be helpful for you to read.

Best wishes,

Jeff

ps...have you every used the medication GHB (gamma hydroxy butyrate (Xyrem) which is currently approved for excessive daytime sleepiness and narcolepsy? Other FDA indication may be approved and are currently being studied as it is an empathogen and makes you want to socialize and to feel more compassionate for others. Off label, it promotes social ability and block the fear/anticipation response and may even help you with your lack of relationship with the ladies. This is just my personal opinion (not medical advice) from my own trial with it both when it was available as a GRASS-"Generally Recognized As Safe Supplement in health food store and also when I used the prescription brand. However, it can cause rebound anxiety as it temporarily increases serotonin/gaba, but the next day the it dramatically increases dopamine.

Trazodone might be an option for you as well.


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poster:CaptainAmerica1967 thread:868223
URL: http://www.dr-bob.org/babble/20081204/msgs/868241.html