Posted by karl on December 19, 2008, at 18:17:06
those who take selegiline or are considering it might try to understand the different feelings they get from the two different actions of the drug, 1) metabolites and 2) mao-b inhibition. if it's the metabolites that are making them feel better, they should know that one can buy the major metabolite of the selegiline molecule, levo-methamphetamine, at the drug store and that they may not need to order selegiline from overseas or pay $600/month for emsam patches. it's called levmetamfetamine now [to try to discourage abuse] and they put it in Vicks Inhalers, although according to wikipedia Vicks soaks a piece of cotton with it and with menthol and camphor, so dosing is obviously tricky if not impossible. i don't know where one could obtain pure levmetamfetamine. if you know, kindly post a follow-up.
if you feel like trying some mao-b inhibition on its own with as little methamphetamine floating around in your system as possible and screwing up your sleep, or already are using selegiline for this purpose and feel it may be helping you, you don't need much selegiline, you don't have to put it under your tongue, and you don't have to take it very often:
"MAO-B is irreversibly inhibited by 90% within 30-90 minutes, and remains so until it can be re-synthesized by the body -- a period of up to 40 days."
http://apple2.org.za/gswv/me/selegiline.structure.pdf
"...by 96 hours (four doses) the inhibition of platelet MAO-B activity is approximately 95% after a daily [oral] dose of 2.5 mg selegiline [hydrochloride], whereas it takes only 48 hours (two doses) for doses of 5 mg and 7.5 mg to achieve this degree of inhibition."
[parentheses mine; the words appear in the abstract if you care to click it below]
and as far as any reasonable science is concerned, it makes no difference to the body whether the selegiline molecule is accompanied by a hydrochloride or a citrate. any website claiming otherwise would do well to provide some scientific explanation and citation for their claim.
something else i've seen talked about is co-supplementation of selegiline with DLPA [dextro/levo phenylalanine]. i don't really see the point here, since phenylalanine is just one of the amino acids that make up the proteins that compose a large part of most humans' diets anyway. for example, 1/4 pound of ground chuck has 783mg of phenylalanine. [http://www.nutritiondata.com/facts/beef-products/6205/2]
poster:karl
thread:869704
URL: http://www.dr-bob.org/babble/20081214/msgs/869704.html