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GSK-3b inhibiton (reasons for AD augmentation)

Posted by linkadge on December 22, 2008, at 21:24:09

GSK-3b inhibition by mood stabilizers decrease depression and increases the brain's responce to serotonin in mice lacking tryptophan hydroxylase.

http://www.sciencedaily.com/releases/2008/02/080207131854.htm

Lithium, valproate and omega-3 are GSK-3b inhibitors. This activity may underly their augmentative effect in clinical depression. I think there is also an interaction between GSK-3b and p11 (gsk-3b inhibition increases post synaptic responsiveness of 5-ht1b receptors).

There is a reciprocol effect too (low serotonin increases gsk-3b activity). GSK-3b also has some regulatory effect on the circadian rhyhtem.

Anyhow, very interesting article.


Linakdge


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poster:linkadge thread:870380
URL: http://www.dr-bob.org/babble/20081214/msgs/870380.html