Posted by seldomseen on December 29, 2008, at 8:39:54
In reply to Use of SSRI leads to white matter losses, posted by linkadge on December 27, 2008, at 22:08:34
The white matter lesions detected were only significantly worse with the use of TCAs and not SSRIs. There was no significant difference with the use of SSRIs.
Even then, the study did not, and could not, prove causality.
In fact, if one looked at the confidence interval for the odds ratio, then in a larger study (the cohort size in the abstract was misleading, not all of the cohort was on ADs), one might actually find a neutral or even protective effect of the SSRIs.
Odds ratios less than 1 indicate protective effects.
Seldom.
poster:seldomseen
thread:871107
URL: http://www.dr-bob.org/babble/20081223/msgs/871271.html