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I have a question about sodium valproate

Posted by NKP on January 1, 2009, at 10:08:46

Suppose a person were on 600 mg sodium valproate daily, taken as 300 mg in the mornings and 300 mg in the evenings. This person wants to stop the sodium valproate, as it is causing debilitating sedation.

The package insert says that sodium valproate has a half life of 15 hours, and peak plasma levels are achieved in 1 to 4 hours, depending on whether the tablets are taken with food etc.

Should the person first taper down to only 300 mg in the evenings, and none in the mornings? Or is it better to stop both the morning and evening doses at the same time?

Thanks.


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URL: http://www.dr-bob.org/babble/20081223/msgs/871771.html