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Re: Is it safe to take Nardil and Anafranil? » davidla

Posted by SLS on January 9, 2009, at 10:48:36

In reply to Is it safe to take Nardil and Anafranil?, posted by davidla on January 8, 2009, at 22:54:20

> I take Nardil and my new psydoc prescribed me Anafranil for my OCD symptoms. Is this a safe combination?
>
> I researched this online and all I'm seeing are warnings that these meds should never be combined.

MAOIs can be combined with desipramine, nortriptyline, and perhaps trimipramine, but not clomipramine nor imipramine. The results of mixing potent serotonin reuptake inhibitors with MAOIs is serotonin syndrome. This is a potentially fatal reaction. I am currently taking Parnate + nortriptyline. I have also safely mixed high dosage Parnate with desipramine. Nardil + imipramine will likely produce a moderate serotonin syndrome, whereas Parnate + imipramine is safe. A proper warning would include the fact that everyone's neurochemistry is unique, and what might be tolerable for one person can be poison to another.

What are your plans?


- Scott

 

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