Posted by SLS on January 23, 2009, at 3:17:40
In reply to Re: Desipramine vs Strattera for adult ADD. » desolationrower, posted by SLS on January 23, 2009, at 3:10:01
> > what makes you think attomoxetine accumlate preferentially in the pfc as compared to desip or whatever?
> >
> > -d/r
>
>
> I thought I recalled reading that in one of Stephen Stahl's Brainstorm publications. Perhaps I am mistaken.There is evidence that individual drugs accumulate differentially across different brain regions, and that this might explain the differences in clinical outcome between two NE reuptake inhibitors. I did find something on cocaine during a quick search on Google:
" Article
Cocaine disposition in discrete regions of rat brain
Dr J. I. Javaid *, J. M. Davis
Illinois State Psychiatric Institute and Department of Psychiatry, University of Illinois at Chicago*Correspondence to J. I. Javaid, Illinois State Psychiatric Institute, 1153 N. Lavergne Ave, Chicago, Il 60651, U.S.A.
Keywords
Cocaine levels Brain regions Serum Disposition KineticsAbstract
It has been proposed that various effects of psychoactive drugs on the central nervous system may be related to the capacity of the drug to selectively concentrate in specific regions of the brain. In rat brain, cocaine effects on striatal and nucleus accumbens dopaminergic systems show quantitative differences. However, the disposition of cocaine in various brain regions has not been reported. In the present studies we examined the cocaine concentrations over time in serum and discrete brain regions of the rat after single intraperitoneal (i.p.) injection. At different time points (5, 10, 20, 30, 60, 120, and 240 min) after i.p. injection of cocaine hydrochloride (10 mg kg-1, free base) the rats were decapitated and cocaine in serum and various brain regions was quantitated by a specific gas liquid chromatographic method. There was large inter-individual variability in different rats at each time-point. The disposition pattern of cocaine in rats after i.p. administration was similar to that observed in humans after intranasal administration. Initial absorption rate was rapid and, on average, the peak levels of cocaine were achieved in 10 min. The cocaine levels remained relatively high over the next 50 min indicating continual absorption, and then declined with a rate such that the levels 4 h after cocaine administration were undetectable in most of the animals. The overall changes in cocaine levels in various brain regions paralleled the serum concentrations. The area under the cocaine concentration-time curve (AUC) revealed more than three-fold differences in cocaine accumulation in various brain regions. This unequal disposition of cocaine may be responsible in part for differential biochemical effects in different brain regions.
Received: 14 May 1992; Revised: 30 September 1992"
http://www3.interscience.wiley.com/journal/112402840/abstract?CRETRY=1&SRETRY=0
- Scott
poster:SLS
thread:875152
URL: http://www.dr-bob.org/babble/20090104/msgs/875566.html