Posted by iforgotmypassword on January 26, 2009, at 7:08:41
the disorientation and general felling of goofiness is still an issue, as is the weakness and exhaustion, but thankfully these are lessening quite a bit. i still delay taking it by an hour or two after when i would usually dose, so i can guarantee doing some things with my senses and wakefulness intact. this need is less of a problem now, thankfully. i would say that i have just reached the point that, with enough caffeine available as a precaution, i am tolerating 200mg (100mg b.i.d) reasonably well.
i was thinking of increasing to (150mg b.i.d.) as this will get me into the clinically effective range of the med (apparently 300mg-600mg). given that range, waiting for 200mg to be effective would seem to be counterproductive, on 200mg it seems i am not suppose to expect anything, i am merely waiting for the point where i tolerate it... which i think i am pretty close to, and would reasonably tolerate an increase (but i will just keep caffeine handy.)
i am very desperate to see if this drug will help me, and there are many factors in my life pressing this urgency (including my tenancy once again.)
again if this drug works, my plan may still be to switch from this drug onto trazodone, eplivanserin, volinanserin, or pimavanserin, since they similarly have the 5-ht2a antagonistic component, but most, apart from trazodone, do not have the 5-ht2c agonist component. this will get rid of the liver worries. it will be interesting when the other drugs come out, but in the meantime, if i benefit from nefazodone eventually, i imagine i will benefit from trazodone's similar actions, and be somewhat prepared for the anti-adrenergic fatigue. it does not seem to have H1 affinity (which i do not react well to at all), but i cannot confirm this. i am under the impression the assumptions that it did have H1 affinity, were just assumptions based on the fact that it is one of the most commonly used antidepressants as hypnotics, and came closely after the reign of major tricylics, where many antidepressants had notable H1 affinity.
poster:iforgotmypassword
thread:876267
URL: http://www.dr-bob.org/babble/20090104/msgs/876267.html