Posted by SLS on January 29, 2009, at 7:08:03
In reply to Re: Endogenous Depression Caused By Lack Of Endorphins » SLS, posted by 4WD on January 28, 2009, at 22:22:27
After doing a wee bit of reading, I see that Subutex might be better-suited for your condition than Suboxone. Naloxone is added to the buprenorphine in Suboxone ONLY to prevent I.V. abuse. If administered I.V., the naloxone induces a withdrawal episode rather than a euphoriant effect.
Buprenorphine is a partial agonist at mu and kappa opioid receptors and a full antagonist at delta receptors. I believe that it is the partial agonism at the mu receptor that places a ceiling on the perception of euphoria, unlike complete agonists like heroin. It doesn't appear that naloxone is necessary in non-I.V. opioid users.
Although I'm feeling pretty good and probably won't need opioids for my treatment, I wish my doctor had been receptive to the idea of using buprenorphine when I presented it to him. You are very fortunate.
I look forward to seeing how you respond to buprenorphine.
Take care.
- Scott
poster:SLS
thread:875814
URL: http://www.dr-bob.org/babble/20090104/msgs/876942.html