Posted by ace on January 31, 2009, at 7:20:29
In reply to Making sense of NARDIL 'poop out' (benzo like?), posted by myco on January 23, 2009, at 18:23:21
> Hey
>
> I understand benzos work by playing off gaba receptors to relieve anxiety and muscle tension and suffer from tolerance/"poop out" after sometime.Hi! Actually I have never heard of Benzo 'poop-out' whatsoever. I have heard of people saying they need higher and higher doses to sustain the same therapeutic efficacy, but I dismiss this.
If one of the beneficial effects (and its my hunch this is what I respond so well to) is associated with gaba is it possible that nardil "poop out", that is often experienced, is the effect of tolerance involving gaba? I'm trying to understand this med fully.
Very hard to say. I am certain Nardil's elevation of GABA in the brain does account for SOME of it's effect, but I think it's efficacy, and poop-out (I am not too sure about this phenomenons validity either), would be interrelated with Nardil's effecting 3 main NT's: 3 that have been identified in depression.
Sorry for such uncertainty, certainly MAOI's warrant much more research,
Ace:)
>
> thnx
>
>
> atypical depression, gad, social anxiety
> 75mg nardil
poster:ace
thread:875681
URL: http://www.dr-bob.org/babble/20090104/msgs/877315.html