Posted by Incubusfan on February 4, 2009, at 19:58:04
In reply to Re: which antidepressants dont cause anxiety » sam K, posted by SLS on February 4, 2009, at 18:36:42
> > doesnt that only hit norepinepherine?
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> It is a mild-to-moderate inhibitor of serotonin reuptake as well, having a dissociation constant of 18-60 Ki (nM). By comparison, desipramine is 200-4250 Ki (nM). The larger the number, the weaker the binding. Desipramine is more selective for NE than is nortriptyline.
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> > So interesting how does that make anxiety better.
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> The best answer to your question is to say that it just does. Years of experience. Amitriptyline would probably work better for anxiety acutely, but not necessarily long-term if the anxiety is part of the depression. Amitriptyline has more potent side effects. Other TCAs that are good for anxiety are doxepin and trimipramine.
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> - ScottWhat do you think of Anafranil for a combination of anxiety, depression, and OCD? Also, is it possible to combine multiple TCAs?
poster:Incubusfan
thread:878003
URL: http://www.dr-bob.org/babble/20090203/msgs/878070.html