Posted by SLS on February 15, 2009, at 7:56:17
In reply to Re: Sertraline + sigma agonist or antagonis? » SLS, posted by SLS on February 15, 2009, at 7:53:24
Here you go, Linkadge:
http://en.wikipedia.org/wiki/Sertraline
"Mechanism of action
Sertraline is primarily a serotonin reuptake inhibitor (SRI). Therapeutic doses of sertraline (50200 mg/day) taken by patients for four weeks resulted in 8090% inhibition of serotonin transporter (SERT) in striatum as measured by positron emission tomography. A daily 9 mg dose was sufficient to inhibit 50% of SERT.[148] Sertraline is also a dopamine reuptake inhibitor, with 1% of its SRI potency,[149] and a sigma-1 receptor agonist with 5% of its SRI potency.[150] Sertraline weakly blocks α1-adrenoreceptors with 110% of its SRI potency.[149][151]"
- Scott
poster:SLS
thread:880228
URL: http://www.dr-bob.org/babble/20090213/msgs/880235.html