Posted by SLS on February 21, 2009, at 6:41:43
In reply to Re: Second-day depression from Trazodone?, posted by Roslynn on February 14, 2009, at 17:40:54
For what it is worth, trazodone is metabolized by the body into a compound named mCPP (m-Chlorophenylpiperazine). This substance is known to produce anxiety and dysphoria. My guess is that as the trazodone levels drop and the levels of mCPP remain elevated at the end of a dosing period, the dysphoria and anxiety will predominate over the hypnotic effect. Smoking makes this disparity worse.
- Scott
poster:SLS
thread:879715
URL: http://www.dr-bob.org/babble/20090213/msgs/881450.html