Posted by myco on March 1, 2009, at 18:21:33
In reply to Re: Seroquel's DA/SA lowering + Nardil = Depression?, posted by bleauberry on March 1, 2009, at 16:32:54
Hi bleauberry,
Youre great to have on our side bleauberry...I love the very logical, calm down lets take this step by step, approach you have with giving clear advice. Ever think about teaching of some form?
I guess I misunderstood how 'antagonism' works? If seroquel antagonizes dopamine and seratonin receptors this means it "blocks" or prevents dopamine and seratonin transmission thus increasing the amount of dopamine and seratonin that 'hang out' in the synaptic gap? And it's sleep effect is due to antagonism of histamine receptors. I think this make sense?
Is that it? sorry for my ignorance man lol im a chef not a biochemist.
I will adjust the dose up and see what happens in terms of mood...but I have a feeling this isn't a "happy drug"...tends to lend to apathy in the least from what I hear.
My main issue, tryin to resolve this, is lack of a proper sleep med. Benzo phobe dr...temazepam only few times a week and my trial of trazodone ended in unpleasant sides with nardil. I dont know where else to turn in terms of sleep meds...kinda why im on seroquel for sleep now. I hope sometime maoi insomnia will become manageable solely with my herbal friends.
thx again
myco> I would explore a different sleep med. It makes zero sense to me to take something that makes me feel worse...on purpose...and expensive...and then go out and have to toy with something to make me feel better while continuing taking the thing I know is making me feel worse. I don't get that.
> Though I do admit, been there done that.
>
> There is other stuff. Lunesta, klonopin, restoril, 7.5mg remeron, trazodone (I hate this one, but hey, some people like it), and how about nortriptyline or maybe cautiously amitriptyline.
>
> If you want an antipsychotic induced sleep, Zyprexa is in my opinion a better choice overall for just about any psychiatric condition. It doesn't have the knockout punch of Seroquel, but it is definitely a sleep inducer and in my opinion is a much better psych med all around.
>
> And the stuff about tyrosine and tryptophan. Well, it aint quite so easy. All that stuff assumes that your genes and your enzymes are going to convert those things into the things you want and through the correct pathways. That's an iffy assumption in anyone with ongoing psychiatric symptoms.
>
> I wouldn't mix either of those with an MAOI anyway.
>
> Seroquel isn't lowering DA or SA, it is actually increasing them as well as NE. Brain concentrations of all three increase on Seroquel or Zyprexa or Risperdal. But at the same time the receptors are being partially blocked from feeling the extra boost.
>
> Personally I would either...increase the dose of Seroquel to see if it feels different in terms of mood, maybe takes on a different character, or ditch it completely and resume the hunt. There is no perfect med that lasts forever, so sometimes you gotta learn to live with the best you got at the time.
poster:myco
thread:883140
URL: http://www.dr-bob.org/babble/20090223/msgs/883273.html