Posted by linkadge on March 8, 2009, at 11:37:29
In reply to Re: Nortriptyline = Tachycardia » linkadge, posted by Vincent_QC on March 8, 2009, at 10:15:00
Nortriptyline is a powerful inhibitor of norepinephrine reuptake. They still havn't really discovered drugs which targed monoamines in the CNS. As a result, drugs like nortriptyline result in increases in cardiac NE. The effect on BP and heart rate is probably dependant on one's genetic disposition. While TCA's tend to increase pulse in almost everybody, the extent of which probably depends on baseline cardiac NE lvels.
You could try a more balanced TCA such as imipramine. Clomipramine is more slective for serotonin and nortriptyine more selective for NE.
Other than that, I assume you have tried the SSRI's(?)
Some people add a beta blocker to a TCA, but I think thats just getting too dirty, and possibly still unsafe.
Linkadge
poster:linkadge
thread:884225
URL: http://www.dr-bob.org/babble/20090304/msgs/884420.html