Posted by bleauberry on March 21, 2009, at 12:04:37
In reply to Re: Why the hell does nothing work the same anymore » bleauberry, posted by mav27 on March 20, 2009, at 20:38:23
> I can't handle anything with noradrenaline.. it makes me agitated, angry , lowers BP seriously, causing fainting spells and causes sexual dysfunction where it feels like someone stabbing me through the prostate with a knife. It also takes away all my energy making me very lethargic even though it's generally considered to be involved in giving energy rather than taking it.
>
> Seratonin just kills all emotions and makes me very sleepy as well as the usual sexual dysfunction (impossible to reach orgasm) It relieves depression but also kills any happiness iam able to feel which meansno more smiling or laughing which iam at least able to do when not on AD's even if iam suicidal.
>> Also nothing is allowed to be combined with MAOIS's here, and TCA's can't be mixed with SSRI's (or similar). We are quite backwards here in AUS.
Yikes. Ok. Got the picture. AUS does make things a bit more limited. I understand the NE and SERT effects you feel. Both somewhat common and make sense. I've experienced them too.
Well, AUS doesn't allow MAOIs and SSRIs combined, do they? But you did it anyway. So what is to stop you from mixing things they don't usually mix? Well, I know the answer, just wanted to make a point. That is, when there is a will, there is a way.
Meds. Ok, so maybe the NE meds you tried were too strong of a dose, and/or not balanced out with an appropriate amount of SERT? What about a low to medium dose of your favorite SSRI (relatively speaking), and a much smaller dose of something like Nortriptyline or Amitriptyline? Or how about Clomipramine by itself? I mean, side by side with Parnate or maybe even a little better than Parnate, Clomipramine is generall still king of the hill. In 50 years nothing yet has been invented that beats it. It is an equal mix of NE and SERT, and maybe all you need is a low dose.
I just get the hunch that even though you have specific effects from either NE or SERT, I can't help but wonder if that picture would change if they were combined. I think they would. It would not be like adding one to the other. It would change the whole flavor of the soup.
5ht2 antagonism. That could be a missing link. That would ptentially counter some of the bad effects you feel and simultaneously enhance the good ones. Something like Clomipramine by itself, or anything else combined with low dose Zyprexa.
If you have not tried the antipsychotics, Zyprexa or Abilify deserve a good look in combination with anything else you try. Their multi-dirty receptor blocking properties can to wonders. These days we have it all backwards...the cleaner a med is the better it works. NOT. In reality, the dirtier a med is, the better it works. That's why SSRIs still have not been able to beat TCAs or MAOIs or Atypical Antipsychotics.
So think dirty! Mix things up. Do a lot of stuff. Don't focus on NE or SERT issues alone. Mess with a bunch of stuff. And instead of just looking at ways to increase concentrations of NE or SERT, look at ways to block receptors and affect dopamine as well. That's where antipsychotics and some of the TCAs come into play.
Sorry, just thinking out loud.
I know, this stuff is wicked hard. I'm just trying to help with some ideas.
poster:bleauberry
thread:886186
URL: http://www.dr-bob.org/babble/20090313/msgs/886385.html