Posted by SLS on April 12, 2009, at 18:40:23
In reply to Nardil and Provigil, posted by Cseagraves on April 12, 2009, at 16:27:20
> Question.
>
> If Nardil makes you sleepy during the day and sleepless and night, would taking provigil be O.K.? Would that help to straighten your sleep cycle or would you still be awake all night?
>
> Have others here tried taking provigil with an maoi? If so, how did you do with that combo?
>
> Just curious.
>
> Courtney
I really like the idea of combining Provigil with an MAOI. I would have added it to Nardil if it had not made my depression worse when I tried it by itself.The only thing is, I have no anecdotal reports to provide you with. You would be a pioneer of sorts.
In any event, your logic regarding the improvement of circadian rhythms using Provigil while taking Nardil is sound. I think it is worth a try. At this point, I am unaware of any contraindication for this combination.
Good luck.
- Scott
******************************************: Sleep Med. 2004 Sep;5(5):509-11.Click here to read Links
Concomitant use of modafinil and tranylcypromine in a patient with narcolepsy: a case report.
Clemons WE, Makela E, Young J.Michael S. Aldrich Sleep Disorders Laboratory, Department of Neurology, University of Michigan, 8D 8702 University Hospital, Box 0117, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0117, USA. ec2285@msn.com
This is a case report of a patient with narcolepsy treated simultaneously with modafinil and tranylcypromine. The concurrent use of these two medications is normally contraindicated based on theoretical concerns. To our knowledge this is the first report of the combined use of these two medications in a patient for any reason. This combination of medications was particularly effective in the treatment of the patient's narcoleptic symptoms and was well tolerated, with no evidence of the potential cardiovascular side effects. Due to modafinil's lack of sympathomimetic activity and unique pharmacological profile, it may be well tolerated with monoamine oxidase inhibitor's (MAOI's) in humans with respect to hemodynamic parameters and concerns of hypertensive crisis. Further investigation would help clarify cardiovascular safety issues in using this combined therapy. We believe that with proper informed consent from the patient and careful monitoring, a combination of an MAOI and modafinil may be a viable treatment alternative in refractory cases of narcolepsy.
PMID: 15341899 [PubMed - indexed for MEDLINE]
- Scott
poster:SLS
thread:890172
URL: http://www.dr-bob.org/babble/20090408/msgs/890206.html