Re: may just be another ssri

Posted by desolationrower on April 15, 2009, at 2:03:08

In reply to Re: may just be another ssri, posted by SLS on March 24, 2009, at 7:29:40

> > > it seems that it may only have 5-ht1a effects in vitro. its lack of effect on extracellular dopamine and noradrenaline is not shared by 5-ht1a partial agonist monotherapy, or when augmenting an ssri.
> >
> > Which 5-HT1a partial agonists DO increase extracellular catecholamine concentrations via that mechanism?
>
> Take a look at this:
>
> http://www.ncbi.nlm.nih.gov/pubmed/18801415?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
> Pretty exciting.
>
>
> - Scott
i've had this study open in a tab in my browser for a while now, and haven't really been able to process it. i think it is pfc 5ht1a->inhibition of gabaB->glutamatergic efferents to VTA->NMDA activation->DA neurone burst activity
-d/r

Thread

Vilazodone - SSRI + 5HT1a partial agonist SLS 3/22/09
Re: Vilazodone - SSRI + 5HT1a partial agonist dcruik518 3/22/09
Re: Vilazodone - SSRI + 5HT1a partial agonist » dcruik518 SLS 3/22/09
Re: Vilazodone - SSRI + 5HT1a partial agonist » SLS Phillipa 3/22/09
Re: Vilazodone - SSRI + 5HT1a partial agonist NickCave 3/22/09
may just be another ssri iforgotmypassword 3/23/09
Re: may just be another ssri » iforgotmypassword SLS 3/24/09
Re: may just be another ssri SLS 3/24/09
Re: may just be another ssri » SLS iforgotmypassword 3/25/09
Re: may just be another ssri » iforgotmypassword SLS 3/25/09
Re: may just be another ssri kenny6 3/26/09
Re: may just be another ssri desolationrower 4/15/09
Re: Vilazodone (NOT Valdoxan) bearfan 11/16/09

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