Posted by bleauberry on May 10, 2009, at 18:47:25
In reply to I'm on a lot of SSRI and I feel great, posted by Deneb on May 9, 2009, at 23:27:23
I suspect it is the Risperdal doing the trick. In combination with ssris, as with other APs, it increases dopamine and norepinephrine levels in specific brain regions, thus balancing out and complimenting what the ssri is doing on serotonin. Plus the serotonin blockade of risperdal is probably doing some good things. Just a hunch based on reading things on pubmed. For example, prozac increased dopamine and norepinephrine levels something like around 50% by itself, but something like 200% when zyprexa was added to it. Those numbers are nowhere near exact, but the overall pattern/trend is. Risperdal or Zyprexa in combo with Prozac increase dopamine and norepinephrine a lot.
Personally I think the Prozac/Zyprexa combo is extremely under-utilized, as is probably the Celexa/Zyprexa, Celexa/Risperdal, Paxil/Risperdal combos. In another example from pubmed, a small group of treatment resistant patients on Milnacipran had almost complete recovery when Risperdal was added, and another case report of the same thing happening when Zyprexa was added.
Not all ssris are the same however. When Zyprexa or Risperdal are added to Zoloft, dopamine is increased but not norepinephrine.
poster:bleauberry
thread:894962
URL: http://www.dr-bob.org/babble/20090505/msgs/895079.html