Posted by SLS on June 20, 2009, at 6:05:16
In reply to Re: Valium defeats Prozac's antidepressant effects?, posted by linkadge on June 19, 2009, at 22:35:00
> I personally believe in the brain metabolism theory of depression.
Which one? Mitochondrial?
> There are the 'depression circuits' that appear to dampen upon sucessful treatment with antidepressants.
Yes.
> Sleep deprivation, for instance, is not going to produce measurable neurogenesis in one night, but (in responders) it does lead to measurable alterations in regional metabolism.
Perhaps, but then, couldn't there be a circuitry thing going on there with changes being exerted by the hypothalamus?
> They can also shut on and off depression in a matter of seconds with DBS. This also corresponds with alterations in brain metabolism.
How do you then separate out the metabolism, which might be a secondary effect, to a change in the activity of afferent circuits? Lightening is still faster than fire.
I am still all over the place when it comes to trying to find the target pathology for MDD or BD. Perhaps there needs to be a convergence of several pathological endophenotypes.
I don't know. Too much information and too little understanding.
- Scott
poster:SLS
thread:902045
URL: http://www.dr-bob.org/babble/20090620/msgs/902220.html