Posted by Brainbeard on June 23, 2009, at 6:43:43
In reply to Re: Sigh. Abilify is now prescribed. What about Luvox? » Brainbeard, posted by Amelia_in_StPaul on June 22, 2009, at 14:17:02
> Exactly. And I'm a writer, who has wasted a lot of time falling into apathy for months on end. ARRGGHI'm a singer-songwriter, mostly, and the problem is that my natural state has become one of serious creative inhibition. It used to be different when I was a regular marihuana user, but that would hardly be a solution in the phase of life I'm in right now..
> That's great. What flavor of depression did you/do you have (or are you mostly taking this for OCD)?
Well, clinically, it might not even be depression; perhaps it should be called 'dysthymia'. I guess 'melancholic depression' would apply more than 'endogenic depression'. In fact, my OCD and my depression are closely intertwined. I'm depressed because I'm convinced that I have been damaged or contaminated and that now life isn't worth living anymore.. That kind of viscuous circle.
> Sounds like you have a great doctor.Ha! Misunderstanding! I do have a great doctor, but guess who the doctor is? That's right, yours truly. My p-doc is just about to fire me because of my pharmacotherapeutical venturings. I think it annoys her sometimes that I know more about some pharmacological details than she does. She's told me that she can impossibly keep up with all the latest research; she just doesn't have the time. Still, she won't let me do the thinking. She'd rather prescribe me a med with serious and possibly dangerous side-effects that is according to protocol than prescribe me an experimental med that has virtually no side-effects but is off the well worn road.
> Do you mean too much dopamine? Interesting. I didn't know that.Not necessarily too much, but dopamine going wrong, at least; dopamine triggering anxiety. Dopamine and noradrenaline are closely connected to the fight-or-flight-response and thus to anxiety.
> I think they [TCA's, ed.] metabolize using 2D6 too. My problems with a couple of TCAs were similar to SSRIs.No no, not all of them. Clomipramine only uses 2D6 a little bit and is mostly metabolized by 1A2 and 3A4. Luvox (fluvoxamine) also doesn't even touch 2D6 but gets broken down by 1A2 and 3A4. Zoloft (sertraline) is metabolized mostly by 3A4; 2D6 plays only a minor role, perhaps it becomes more prominent on higher dosages, when sertraline also begins to inhibit 2D6. For imipramine too, 1A2 and 3A4 are more important than 2D6. Citalopram (Celexa) is not metabolized by 2D6 but by 2C19. Escitalopram (Lexapro) is mostly metabolized by 2C19 too, but also by 3A4 and 2D6.
So, from a 2D6 point of view, Luvox or Celexa would be completely fine.
> Yes, I have OCD too. The pure O version (I know that's a misnomer; I do have mental compulsions, after all).Pure O here too. I stopped performing classical (fysical) compulsions ages ago. Well, there are still some compulsive acts, but I don't wash my hands hundred times a day anymore, to mention something.
I'm buying most of my meds myself, over the internet. My p-doc was so friendly to prescribe the sertraline (Zoloft) for me. She didn't want to prescribe the ondansetron. I can only hope that I'll find a p-doc who writes prescriptions like there's no tomorrow.
>
Acupuncture - not for me. I stay clear from most alternative kinds of health care. Too much occultism. Wrong roots (just my opinion). In my country (Holland), most of that stuff is being covered though.> Well, we'll see anyway. I just know I am not going back the SRI route. And I am NOT going on an antipsychotic. I am not wrecking my body any more.
Hate to say it, but psychological problems can wreck your body (and your life, your relationship, etc.) too. Sometimes one has to choose the lesser evil.
> Good luck to you. Sounds like you have a good idea of what's going on with you and what will work. You must have a heck of a good pdoc.
I sure have. ;) No, thanks. And good luck to you.
poster:Brainbeard
thread:902046
URL: http://www.dr-bob.org/babble/20090620/msgs/902725.html