Posted by sukarno on June 26, 2009, at 12:09:02
In reply to Has anyone else noticed that....., posted by Michael Bell on June 21, 2009, at 23:28:22
"a) medications that have norepinephrine reuptake inhibition as one of their mechanisms of action, such as reboxetine, and tramadol, increase emotional instability, increase the feeling that others are judging you/staring at you, etc., and increase sensitivity to perceived rejection?"
Pamelor (nortriptyline) is a norepinephrine reuptake inhibitor and it worked very well for me. Maybe SNRIs work differently? I had no panic attacks or depression while on Pamelor and also felt full of motivation and could concentrate easily on any task at hand. I had straight A's in school while on that medication.
"b) Drugs that are effective for the physiological aspects (heart pounding, sweating, abject terror) of social anxiety, such as klonopin and Nardil, don't help with the "social paranoia" aspect of social anxiety, meaning the beliefs and thought processes that people are looking at them, judghing them negatively, etc."
I found that Klonopin and other benzodiazepines lower my inhibitions to the point where I am able to socialize with others and feel a sense of confidence. It makes me worry less about what others think. Everyone is different though in their reactions to drugs.
"c) SSRIs + Antipsychotics are pretty damned good for the following: anger outbursts, feelings of frustration, and social parania."
I don't know about antipsychotics, but SSRIs tend to cause emotional blunting/numbing and are helpful for that. Prozac made me feel very stable, yet numb so that I didn't feel particularly happy or sad about anything. It is hard to describe, but I would say it felt "artificial". I also didn't feel angry about anything either. Amazing stuff in that regard. ;-)
"d) klonopin, on its own, causes depression and anger issues to worsen."
Yes, definitely. I experienced depression. Benzodiazepines lower inhibitions, so people prone to anger can experience outbursts of anger or even rage, although that is not common. I read recently that BZDs stimulate the aggression center of the brain.
"e) drugs that increase dopamine production and availability as the main effect increase anger, frustration and rumination?"
Well, I only take Stablon, which is mild in its dopamine-boosting effects, but it is enough that I feel a desire to gamble or seek out excitement or pleasure. Fortunately I can restrain myself and not gamble or anything else, but dopamine indeed increases reward seeking behavior...at least I think it does from what I read.
poster:sukarno
thread:902542
URL: http://www.dr-bob.org/babble/20090620/msgs/903306.html