Posted by Sigismund on August 7, 2009, at 15:20:51
In reply to Re: sleep on Agomelatine, posted by Hundredwaters on August 6, 2009, at 21:14:43
Well, it's not necessarily as straightforward as one might think. It as, as you know, an agonist at melatonin receptors and an antagonist at 5ht2c.
So, when you take it you *do* get tired.
But if you take too much (whatever that might mean) the 5ht2c antagonism is going to somehow or other increase the dopamine feeling. I don't know anything about how that happens, but it can be felt obviously enough.
That first night I mentioned, when I woke up after a couple of hours, I thought 'boy, smart drug', meaning it felt humane and not bad for me in the way I expect psych drugs to be.
My idea is this....eventually, after a few months, your body will be used to it to a certain extent. At that point it is *very easy* to raise the dose. I wouldn't be in a hurry to raise it too early. Doubtless you want the AD effect? It has to be said that the AD effect off agomelatine is mild. It's just that (apart from the liver enzyme thing) there is no downside (that I am aware of).
So, yes, it does help sleep. But that help is to be found at a dose where your body does not consider enough to go making more dopamine available or whatever that thing is.
Does that make it somewhat clearer?
poster:Sigismund
thread:910561
URL: http://www.dr-bob.org/babble/20090801/msgs/910792.html