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Re: Popular Antidepressants: How They Stack Up

Posted by SLS on August 7, 2009, at 16:29:09

In reply to Re: Popular Antidepressants: How They Stack Up » Alexanderfromdenmark, posted by Sigismund on August 7, 2009, at 16:13:37

> I wonder if agomelatine does what mirtazepine does without the side effects?

I think the blocking of NE alpha2 receptors by mirtazapine sets the two drugs apart. What I don't know is at what dosages the different effects of mirtazapine become robust. I think one might need to take 45mg in order for the pro-noradrenergic effects to become prominent. This might explain why higher dosages are less sedating than lower dosages.

Maybe the NE alpha2 blockade is not necessary for some people. Then, as you say, agomelatine might represent the better choice.


- Scott

 

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