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Re: histamine receptors dimebon antagonises?

Posted by SLS on August 29, 2009, at 6:55:28

In reply to histamine receptors dimebon antagonises?, posted by iforgotmypassword on August 29, 2009, at 1:29:29

Wiki:

"Pharmacology

Dimebolin appears to operate through multiple mechanisms of action, both blocking the action of neurotoxic beta-amyloid proteins and inhibiting L-type calcium channels,[10] modulating the action of AMPA and NMDA glutamate receptors,[11] and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores,[12] which are believed to play a role in the cell death that is associated with neurodegenerative diseases and the aging process.[13] It also blocks a number of other receptors including alpha-Adrenergic receptors and the serotonin receptor subtypes 5-HT2C, 5-HT5A and 5-HT6.[14]"

Interesting drug. It is currently available in Russia.


- Scott

 

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