Posted by jasmineneroli on September 27, 2009, at 21:56:27
In reply to Heroic combos, posted by X-ray on September 26, 2009, at 13:19:02
> Hi,
>
> I have been looking for a drug to use in combination with Wellbutrin.
>
> From Essential Psychopharmacology by Stahl:
>
> Heroic combo 8:
> Mirtazapine+bupropion
>
> NE is double-boosted
> 5HT and DA are single-boosted
>
> Can anyone explain what this means?
>
> Best regards,
> X-ray
>
> P.S. The point is to use safe and rational drug combinations
> that exploit expected pharmacological and molecular synergies
> while even promoting mutual tolerabilities.
> (Heroic combos, Stahl)I'm guessing they mean that since both mirtazapine & bupropion boost NE (norepinephrine), Combo 8 "double boosts NE".
And since only bupropion affects DA (dopamine), and only mirtazapine boosts 5HT(serotonin), the Combo "single boosts DA and 5HT"
Sometimes, Wellbutrin can make people anxious and have insomnia. Sometimes Remeron can cause excess drowsiness, and a contented apathy. The suggested Combo 8 might balance their individual effects well.
Hope that helps a bit.
I've never heard of that book/publication. Sounds really interesting. Thx for mentioning it.
Be well.
J
poster:jasmineneroli
thread:918591
URL: http://www.dr-bob.org/babble/20090921/msgs/918771.html