Posted by yxibow on October 15, 2009, at 14:20:59
In reply to Abilify and heat intolerance/sweating, posted by efishy on October 14, 2009, at 20:58:39
> I am a college student on abilify and i have been having a problem for the last year with heat intolerance and sweating [caused by abilify]. I tried to switch to serdolect half a year ago, but then switched back to abilify because of weight gain.
>
> Now i am considering switching to zeldox, since the side effects of abilify are a big disadvantage. Before i do that i want to share my latest thoughts on the cause of this problem.
>
> My theory is that the heat intolerance is caused by a disruption of the 5-ht1a (serotonin 1a) receptor. Abilify is partial agonist of this receptor.
>
> I found that serotonin 1a, 2a, and 2c affect temperature regulation. However it seems that all 2.gen. AP's affect 2a and 2c. Therefore i thought it might be 1a causing the heat intolerance in abilify.
>
> If this is true then i was thinking maybe a 5-ht1a antagonist might help. The only one i could find was pindolol, and this drug doesn't seem too good either.
>
> I am interested in hearing anyone else's thoughts on this subject.Body temperature regulation is a listed side effect of Abilify.
I know its also listed for Seroquel.
It is probably common among certain atypicals.
It hasn't been reported with Geodon (Zeldox), but the same comments do apply also from the PI:
"Body Temperature Regulation - Although not reported with ziprasidone in premarketing trials,
disruption of the bodys ability to reduce core body temperature has been attributed to antipsychotic agents. Appropriate care is advised when prescribing ziprasidone for patients who will be experiencing conditions which may contribute to an elevation in core body temperature, e.g., exercising strenuously,
exposure to extreme heat, receiving concomitant medication with anticholinergic activity, or being
subject to dehydration"
-- tidings.
poster:yxibow
thread:920950
URL: http://www.dr-bob.org/babble/20091012/msgs/921025.html