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New Antidepressant for Anxiety? - Valdoxan

Posted by tiopenster on October 23, 2009, at 10:14:51

There's a new Anti-depressant out in the EU and Canada called Valdoxan. I need help knowing from you experts out there more about it's mechanism of action. I don't understand the agonist/antagonist thing.

Anytime I take something that affects Serotonin, I respond with increased anxiety, which is a problem because I'm trying to treat GAD. I've tried all the SSRI's. Since this has a unique mechanism of action, I'm having a hard time figuring out how this Valdoxan works and how I would respond.

Valdoxan.com says that Valdoxan is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist. Valdoxan increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin.

It says that it's a 5HT2c antagonist but it doesn't affect extracellular serotonin. That seems like a contradiction. If I don't respond well to things that affect serotonin, will I react badly to this?

I'm assuming here, of course, that I can buy this drug from Canada.


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poster:tiopenster thread:922108
URL: http://www.dr-bob.org/babble/20091021/msgs/922108.html