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Re: Serotonin and norepinephrine » SheilaC

Posted by softheprairie on October 29, 2009, at 5:20:27

In reply to Serotonin and norepinephrine, posted by SheilaC on October 28, 2009, at 16:59:17

> Does anyone know the ratios of the various SNRIs? How much they effect Serotonin and norepinephrine?
>
> I've noticed that Cymbalta and Pristiq do not bother my bladder like the SSRIs do (serotonin bothers my bladder).
>
> Now that I have failed both Cymbalta and Pristiq I am looking for another med similar to Pristiq.
>
>
>

Desipramine (a TCA) just acts on norepinephrine!
No known serotonin influence.
I consider it an anchor of my cocktail that I am currently pleased with.
I am at a high dose of it -- 300 mg/day.
The available pill strength starts as low as 10 mg, if I recall correctly.
Now, I will admit I have cardiac effects from it (heart beat over 100/min, palpitations, nervousness), but they are controlled with an addition of the beta blocker nebivolol/Bystolic.

Good luck!

 

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URL: http://www.dr-bob.org/babble/20091029/msgs/923288.html