Posted by SLS on November 16, 2009, at 7:36:19
In reply to Re: Dangerously close to the end of the road. Help » SLS, posted by delna on November 15, 2009, at 16:40:41
> > Reboxetine (Edronax) is a selective NE reuptake inhibitor. I don't think it has any antihistaminergic properties that would otherwise sedate you. Have you ever tried it?
> I was planning on adding that to the Effexor instead of the wellbutrin. I need the serotonin element for the OCD but of course I can get that from any SSRI like lexapro which is totally non-sedating (but does not impact my depression at all).Clomipramine (Anafranil) might be helpful if it doesn't sedate you. It is good for both depression and OCD. I didn't find it at all sedating. I have seen it recommended to combine clomipramine with an SSRI for treatment resistant OCD. If OCD remains a problem, you can try adding Namenda (memantine). I can't speak from personal experience, but I have read good things about it. I did try Namenda as an augmenter for depression. I did feel a little better in the first week of treatment. Thereafter, it was not helpful to me.
> Do you feel Edronax is a good AD on it's own
No. I think it is a piece of crap.
However, some people do respond well to it. I would rather include things as possibilities than overlook potential treatment success by being too exclusive. I thought that Edronax might offer you NE reuptake inhibition without sedation. I reacted very badly to Edronax. It pushed me into an anxious suicidal state within days of starting it. Yet, desipramine, another selective NE reuptake inhibitor, has treated me well in the past. I guess selective is a relative term. We really don't understand all of the effects of the different antidepressants. In addition, the location of effect is just as important as the effect itself. It is possible that Edronax and desipramine accumulate in different areas of the brain, despite having the same effect on NE reuptake.
> Sorry to be such a bother.
Yes, I lost sleep last night agonizing over how much of a bother you are.
:-) <smile>
Silly.
- Scott
poster:SLS
thread:925800
URL: http://www.dr-bob.org/babble/20091107/msgs/925920.html