Posted by bleauberry on November 30, 2009, at 17:59:26
In reply to Leaden, achy muscles on Nardil, posted by pedr on November 30, 2009, at 11:28:06
This is a very difficult subject and I have never encountered anyone with an explanation or a fix. I think it has something to do with the nervous system, which is no help to us. Hypotension is a maybe a reasonable player, but I doubt it alone explains the whole spectrum of the leaden leg syndrome. I'm not even sure it is a player. I have had, and have known people that had, extremely low blood pressure but did not have the leaden leg thing.
Some people are sensitive to sulfur compounds. Nardil and Parnate have a lot of sulfur. Sulfur tends to mobilize and stir around stored heavy metals such as lead and mercury from fat tissues. A very common symptom of that is leaden leg muscles.
People with Lyme disease report so often of strange leg things...leaden, weak, crawling, tingling, whatever, weird stuff, varies widely from person to person...that is usually not evident or not a problem until some other substance from a food, diet, herb, or medicine provokes it. No one has a clue what's going on, except that it is something in the nervous system.
Sulfur kills many pathogenic organisms. A common symptom of die-off is weak legs.
No doubt there is some adapting going on within the adrenal system, the pituitary system, and who knows what else. These things take months to adapt and adjust, with bizarre unexplainable symptoms in the transition.
We have not a clue what these meds are doing with levels of dietary minerals and salts or water. Just another mysterious variable.
I do not have experience or expertise with the MAOIs, just the knowledge of what users have reported here over the years. I think the general consensus is that whatever weird side effects there are, usually are mostly minimal or gone somewhere in the 9 month to 18 month time period.
I don't know if you've been on it that long.
poster:bleauberry
thread:927523
URL: http://www.dr-bob.org/babble/20091127/msgs/927592.html