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Re: How fast do stimulants elevate mood? » conundrum

Posted by SLS on December 5, 2009, at 13:30:29

In reply to Re: How fast do stimulants elevate mood? » SLS, posted by conundrum on December 5, 2009, at 12:51:41

> SLS, what helped you get back into color?

Transiently, I have had this happen briefly with rapid-cycling, imipramine, and Nardil. I once had an extended response to a combination of Parnate and desipramine.

> My doc thinks I need an SNRI. Maybe he's right. Wellbutrin and Ritalin didn't help with mood at all and I've never tried an SNRI.

You might want to ask your doctor if it would make any sense for you to remain on the Wellbutrin and combine it with one of the SNRIs or even Lexapro.

> I always though Ritalin and Wellbutrin increased norepinphrine anyways, and SSRIs didn't work so I didn't see the point in combining the two.

It is an attractive idea to think that we can design a treatment around what scientists speculate are the mechanisms of actions of drugs. Even with the myriad data that has been gleaned from studying mental illness, very little is understood as to how to assemble the pieces of the puzzle. The more you know, the more you appreciate how much you don't know. In other words, I don't think it would be a good idea to exclude an evidence-based treatment based upon a personal theory. Although there is now some light penetrating the black-box, I don't think that there is quite enough to avoid some measure of trial-and-error.

I had a partial response to a combination of Effexor and nortriptyline. Unfortunately, it was later discovered that I had been underdosed on the nortriptyline. I was taking only half of what I needed. If I don't feel much better than I do now on my current treatment, I would consider returning to the Effexor and nortriptyline at the appropriate dosages.


- Scott

 

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