Posted by delna on December 12, 2009, at 0:54:09
In reply to Re: hashimoto's thyroditis..phillipa/ anyone? » delna, posted by Phillipa on December 11, 2009, at 18:08:30
> Hi Delna should have written you sorry I didn't. Don't fear Hasimotos. At first I always did. Once it's regulated to normal levels you should feel much better. It is notorious for fatigue. I get a newletter from Mary Shoman. I will send a copy so you also sign up. I'd love to see the paper you mentioned as I've never come up with any indication that it's related to bipolar. Don't worry sweetie you'll be fine. Have you started on a thyroid med or is the doc going to watch. No it doesn't mean more autoimmune diseases either. Very common in females especially. Love Phillipa
Hi Phillipa,
Thanks for that. I feel better now.:)
does the fatigue get better with treatment or is it something you always battle with? What is your TPO-Ab count? is that how you were diagnosed?
No, I have not started treatment yet. My doctor wants to start next week- he was just waiting for all the reports to come in. I'm also having tests for adrenal fatigue, just in case
Love DThis is the paper:
Biol Psychiatry. 2007 Jul 15; 62(2):135-40. Epub 2006 Dec 4.
Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?
Vonk R, van der Schot AC, Kahn RS, Nolen WA, Drexhage HA.
BACKGROUND: Both genetic and environmental factors are involved in the etiology of bipolar disorder; however, biological markers for the transmission of the bipolar genotype("endophenotypes") have not been found. Autoimmune thyroiditis with raised levels of thyroperoxidase antibodies (TPO-Abs) is related to bipolar disorder and may be such an endophenotype. This study was intended to examine whether autoimmune thyroiditis is related to the disease itself, to the (genetic) vulnerability to develop bipolar disorder, or both.
METHOD: Blood was collected from 22 monozygotic (MZ) and 29 dizygotic (DZ) bipolar twins and 35 healthy matched control twins to determine TPO-Abs.
RESULTS: The TPO Abs were positive in 27% of the bipolar index twins, 29% of the monozygotic bipolar cotwins, 27% of the monozygotic non bipolar cotwins, 25% of the dizygotic bipolar cotwins,17% of the dizygotic nonbipolar cotwins, and in 16% of the control twins. Repeated measures analysis of covariance on log-transformed absolute TPO-Abs values revealed significantly increased mean TPO-Abs levels in discordant twin pairs as compared with healthy twin pairs,whereas no difference was found between bipolar patients and their (discordant) non bipolar cotwins.
CONCLUSIONS: This study shows that autoimmune thyroiditis is related not only to bipolar disorder itself but also to the genetic vulnerability to develop the disorder. Autoimmune thyroiditis, with TPO-Abs as marker, is a possible endophenotype for bipolar disorder.
poster:delna
thread:928873
URL: http://www.dr-bob.org/babble/20091206/msgs/928940.html