Posted by linkadge on December 23, 2009, at 18:25:37
In reply to Re: Slow Down!, posted by West on December 23, 2009, at 11:32:07
>Is there anything on the web to say it causes >psychosis? I think you're confusing this with >the dissociative high.
No, I don't think so. Google it yourself ketamine + psychosis. Ketamine (and other NMDA antagonists like PCP) have been known for a long time to produce psychotic reactions in certain individuals and animal models. In addition to being a NMDA antagonist (which enhances dopamine release), ketamine inhibits the reuptake of the three primary monoamines (with higher affinity for dopamine transport). In addition, ketamine displays intrinsic agonist affinity for the d2 and 5-ht2a receptors.
Because ketamine is known to produce psychosis, it is often used as a model for schizophrenia (the NMDA model). Amphetamines are also known to cause psychosis (when used recreationally), but the two types of psychosis differ in their clinical presentation. Amphetamine psychosis tends to be the more paranoid type, wherase NMDA PCP and ketamine psychosis tends to be the more disorganized type (ie loose associations, illogical/delusional thinking, nonsensicle speech, cognative disturbances).
The NMDA model of schizophrenia is the basis for testing agents like glycine which act as partial agonists at the NMDA receptor and appear to alleviate many of the symptoms of ketamine / PCP psychosis.
Linkadge
poster:linkadge
thread:930267
URL: http://www.dr-bob.org/babble/20091217/msgs/930586.html