Posted by mtdewcmu on January 2, 2010, at 13:55:17
In reply to Re: Everything You Ever Wanted To Know About Savella, posted by SLS on December 26, 2009, at 17:20:45
> > My own opinion...this drug is probably a potent workhorse in combinations with SSRIs or antipsychotics, though by itself it is plenty impressive.
>
> To paraphrase something you said in an earlier post, if it were so impressive, you would hear more about it and see more people using it.
>
> I have my doubts about milnacipran. However, I will not overlook it or exclude it from consideration. It might be that this drug has not been made visible enough to clinicians as an antidepressant.
>
>
> - ScottGoing by that study by Cipriani, et al, it appears that the effectiveness of SNRIs is inversely related to their preference for norepinephrine over serotonin. So,
Effexor > Savella > Cymbalta > Reboxetine
It seems that serotonin has a far greater influence on depression.
The preferences for serotonin from high to low:
Effexor: 116
Savella: 9.15
Cymbalta: 7.23
Reboxetine: 0.121-from Goodman & Gilman.
Efficacy according to Cipriani, et al, from high to low:
Effexor: 1.28
Savella: 1.01
Cymbalta: 0.99
Reboxetine: 0.68The numbers are relative to Prozac.
poster:mtdewcmu
thread:931002
URL: http://www.dr-bob.org/babble/20091227/msgs/932139.html