Posted by SLS on March 22, 2010, at 12:34:05
In reply to Getting worse :(, posted by Frustratedmama on March 22, 2010, at 10:28:09
> Just put a call into the doctor. Not doing well, so agitated! The librium was always on board so that wasn't a change- but the pristiq to savella was....and now it seems worse than before. hmmmm.....this stinks!
It seems as though some people need in excess of 100mg of Savella to treat depression.
Savella has a short half-life - 7 hours. Are you taking it twice a day?
"According to a pooled-data analysis, the remission rates in patients treated with venlafaxine (an SNRI) and SSRIs were 45% and 35%, respectively.[14] However, the placebo remission rate was 25%. The remission rate in the current study was 31.7% with a dosage of milnacipran 100 mg/day; furthermore, many patients with an inadequate response to this dosage responded when the dosage was increased to 150 mg/day, such that the cumulative remission rate was 63.4%. Furthermore, a marked improvement was noted in HDRS items 1 ('Depressed Mood') and 7 ('Work and Interests') in patients achieving remission with both milnacipran 100 mg/day and milnacipran 150 mg/day. The importance of these residual symptoms in determining the long-term outcome of depression has been emphasised.[15] Our results suggest that milnacipran can be administered at a dosage of 150 mg/day for the treatment of major depression when a dosage of 100 mg/day cannot achieve a satisfactory effect, and indicate that 150 mg/day of milnacipran may be a useful therapeutic option in the treatment of major depression."
http://www.medscape.com/viewarticle/528303_4
- Scott
poster:SLS
thread:940085
URL: http://www.dr-bob.org/babble/20100318/msgs/940408.html