Posted by bulldog2 on March 31, 2010, at 17:29:47
In reply to Re: Is anyone here taking a tricyclic that works?, posted by hopefullynow on March 30, 2010, at 14:26:32
> Hy, I am on a combination of Anafranil(TCA) 25 mg and Maprotiline (TCA-NRI) at 75 mg.As an addon i take 1000 mg of Glucophage to stop the ravenous hunger from the meds-by the way, it works wonderful!.Anafranil worked long time ago, and always pull me from the deepest episodes of depression and anhedonia.Being an anhedonic it's not a fiable option on the long run without an NRI, i suggest you nortryptiline, maprotiline is dirtier and harder to tolerate.The addition of a NRI gives me calm and energy - but strage, only combined with Anafranil.Anafranil....I can't compare with any ssri, snri or any ad, it really works, even better than amitryptiline.I could feel a sense of joy that no other AD ever gave me and i suppose that this different sense of well being is not given by the fact that it targets serotonin, i feel it's about a combination of serotonin and opoid systems involved in its action.
>
> As an add on i take risperdone 0.75 mg at bedtime and 2 mg clonazepam, anafranil could be very energetic, so i am sure i can sleep ok.Now, I try to augument the SRI+NRI with a tiny amount of buspirone(5 mg)for enhancing the AD's response.SO, REALLY, THERE IS HOPE AFTER SSRI...the ol' good tca's do wonders...sometimes.I'm in remission after 10 years of hundred of combinations, you name them.I don't have a phobia of drugs so i tried everything on this planet, except stimulants, MAOI, pot or other street drugs.
>
> This combo allows me to tweak doses independently and to change the ratio of SE/NE/DA/GABA after how it feels.
>
> So my regimen is:
> anafranil 25 mg
> maprotiline 75
> buspirone 5-10 mg
> risperdone 0.75
> clonazepam 2mg
> Glucophage (metformin)1000-1250 mg sperad all over the day in 3-4.
> All drugs except Glucophage are taken at night to avoid sedation and cravings.I woke up refreshed, after 7-8 hours of sleep, and i feel better and better!!!
>
> I hope this post will help, all the best economist!
>
>
>
> > I am done with the SSRIs and SNRIs. I'm on EMSAM right now with no effect. So I'd like to suggest something to my doctor next time. I'm suffering from anhedonia and lack of interest in everything around me.
>
>Very nice combo! I thought anafranil also targets ne? You seem to require such a large dose of maprotiline. Wouldn't this be the drug that plays the biggest part in your combo?
Here's a qoute of yours
Anafranil worked long time ago, and always pull me from the deepest episodes of depression and anhedonia.Being an anhedonic it's not a fiable option on the long run without an NRI, i suggest you nortryptiline, maprotiline.
Does it cause anhedonia? You say it pulls you out of anhedonia but being anhedonic it's not a viable option for the long run...What do you mean by this?
Any sexual sides on this combo?
Thanks for your great post..
poster:bulldog2
thread:941444
URL: http://www.dr-bob.org/babble/20100328/msgs/941534.html