Posted by ed_uk2010 on April 6, 2010, at 13:48:29
In reply to Quick poll: Amitriptyline or Doxepin, posted by tensor on April 6, 2010, at 13:35:41
> Which one would you choose for TRD with anxiety? Did well on nortrip once but pooped-out after a year, made me tired, too much NE? If not too much work, some pros and cons (if you have own experiences) for the two would be great!
>
> Thanks,
> MattiasI wouldn't recommend doxepin for severe depression. It's mainly an antihistamine - a very strong one indeed! Very low doses are useful for chronic insomnia. It's also used to relieve itching eg. in urticaria or uncontrolled eczema. Doxepin is a very weak 5-HT/NE re-uptake inhibitor. It's not as well established for depression as other TCAs.
Amitriptyline is certainly an effective antidepressant but it's very sedating. Why not consider a less sedating tricyclic such as imipramine? Also, clomipramine causes some sedation but not as much as amitriptyline.
poster:ed_uk2010
thread:942481
URL: http://www.dr-bob.org/babble/20100406/msgs/942483.html