Posted by bulldog2 on April 10, 2010, at 12:33:37
In reply to Re: TCA's With Opioid Actions?, posted by SLS on April 10, 2010, at 12:08:33
> > I've seen this statement made on more than one occassion in reference to TCAs. Is there any scientific proof that any tca's have any influence on opioid receptors and which tca's would that be true for?
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> I'll be interested to know more about this, too. I read that some TCAs inhibit activity at kappa opioid receptors. That would make sense, I guess, as stimulation of these receptors can produce dysphoria. Also, kappa antagonists produce behavioral changes in rats that resembled those of TCAs.
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> - ScottSomething about the tcas make them more effective than the ssris for moderate to severe depression. I guess tcas are more effective than the modern snris. I was wondering if the difference was activity opioid receptors? tcas seem to be the most effective of the ads for pain. Also there seems to be some evidence that the tcas moderate activity at the nmda receptor.I wonder what effect that has on the neurotransmitters.
poster:bulldog2
thread:942955
URL: http://www.dr-bob.org/babble/20100406/msgs/942963.html