Posted by bleauberry on April 12, 2010, at 17:50:12
In reply to Pseudoephedrine (sudafed), posted by blueboy on April 9, 2010, at 9:52:55
Your report does not surprise me. I can relate. I felt the same kind of rapid improvement on Yohimbe, and then later on Milnacipran. The thing they both had in common...strong boost in norepinephrine. The norepinephrine thing alone can be misleading...why didn't TCAs work?...why not MAOIs?...why not stimulants?...I think the exact mechanism of the agent is just as important, if not more so, than what its end result is. For example, sudafed will immediately make more NE available at the synapse, but so will any NE drug. So why does one work and not the other? Obviously something more complicated going on that we don't understand. And why would not DLPA or tyrosine work, since they are making NE, but sudafed which is a direct replacement for NE does work? Ya know? Too complicated for mankind at this time in history.
I am a bit surprised the docs weren't more aware of the potency of NE in psychiatric disorders. The focus all seems to be on serotonin and secondarily dopamine. The so-called NE drugs like cymbalta and effexor are so misleading because they barely impact NE at all compared to what they do to serotonin.
Anyway, I'm real excited for you. You want to lose weight as well, which is an added bonus.
I would suspect the main problems going forward might be:
1. Keep an eye on blood pressure.
2. Might possibly need to take short drug holidays to prevent tolerance.
poster:bleauberry
thread:942830
URL: http://www.dr-bob.org/babble/20100406/msgs/943214.html