Posted by SLS on April 27, 2010, at 19:43:51
In reply to Re: Multiple drug exposures and treatment resistence, posted by linkadge on April 27, 2010, at 19:35:24
> >That you have become resistant to the drug that >you responded to previously gives evidence that >something in the brain has changed since your >initial exposure.
>
> Not necessarily. One factor that people sometimes fail to account for is life circumstances. Looking back, when celexa worked, most other things in my life were in check. When I retried it, it didn't work, but my life was in a much more uncontrollable state.
>
> >We know that exposure to these drugs leads to >changes in receptor sensitivities. Perhaps such >changes in dynamics persist after drug >discontinuation.
>
> Sure, certain receptors become less senstive after drug exposure, but during drug withdrawl, the receptors are not going to become any *less* sensitive.
>
> >I guess it is also possible that this treatment >resistance would have occurred anyway as a >result of the natural course of the illness.
>
> Some studies show progressive loss of grey matter and hippocampal volume in depression. Actually some studies link SSRI exposure to acellerated grey matter loss, but thats a different thread.
>
> >I became unresponsive to Nardil within two weeks >of its being discontinued and subsequently >restarted. Pulsing of antidepressants is >probably a bad idea for some people.
>
> Well, the other possibility too is that the drug may have stoped working *anyway*.
Sure.
- ScottThe measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:944856
URL: http://www.dr-bob.org/babble/20100425/msgs/945330.html