Posted by linkadge on May 8, 2010, at 7:51:33
In reply to Re: How can I get the SNRI effect without using SNRI, posted by tensor on May 8, 2010, at 5:08:21
Not all the NRI's have equal secondary binding effects. Nortriptyline probably causes less anxiety / insomnia than desipramine since it interacts with 5-ht2a and histamine more potently.
Wellbutrin (although touted as having N/DRI effects as primary MOA) is thought to exert its antidepresant effects through cholingeric receptor interaction or even monoamine release rather than reuptake.
Linkadge
poster:linkadge
thread:946689
URL: http://www.dr-bob.org/babble/20100504/msgs/946763.html