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Re: How can I get the SNRI effect without using SNRI

Posted by linkadge on May 8, 2010, at 7:51:33

In reply to Re: How can I get the SNRI effect without using SNRI, posted by tensor on May 8, 2010, at 5:08:21

Not all the NRI's have equal secondary binding effects. Nortriptyline probably causes less anxiety / insomnia than desipramine since it interacts with 5-ht2a and histamine more potently.

Wellbutrin (although touted as having N/DRI effects as primary MOA) is thought to exert its antidepresant effects through cholingeric receptor interaction or even monoamine release rather than reuptake.

Linkadge



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URL: http://www.dr-bob.org/babble/20100504/msgs/946763.html