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Re: Curious about Moclobemide » bearfan

Posted by SLS on May 14, 2010, at 18:22:36

In reply to Curious about Moclobemide, posted by bearfan on May 11, 2010, at 14:08:12

> I've read a few reports that Moclobemide is nowhere near as strong as the reversible MOAIs, but I was wondering how it compares to traditional SSRIs (including lower does Venlafaxine). How is the tolerability vs the efficacy?

As best as I can tell, moclobemide is not as efficacious as SSRIs for moderate to severe depression. It can produce an improvement during the first week at a low dose, but this rarely lasts. More often than not, people must raise the dosage again and again in an effort to maintain a response. Eventually, they reach 1200mg and fail to respond further. At one time, moclobemide was one of the most widely prescribed antidepressants. Not anymore.

I tried moclobemide and reacted very badly to it. It severely exacerbated my depression.

Moclobemide does not usually produce significant side effects. It might not hurt to try it if you can afford the time. I cannot guarantee that it won't work.


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