Posted by bleauberry on May 15, 2010, at 20:47:41
In reply to Starting Milnacipran, posted by vic80 on May 15, 2010, at 13:33:55
I do believe milnacipran will help with the apathy anhedonia stuff. For me that didn't really start to happen until the end of the second week on it.
I think overdosing on any reuptake inhibitor...NE or serotonin, doesn't matter...will cause the apathy thing. And in my opinion, milnacipran is dosed much too high. Not that the high doses aren't fine for some people, I just think they are over-assumed as being the standard for everyone. To me, a 25mg dose is a high starting dose. The starter pack begins with 12.5mg. For me, 6.25mg 3 times a day was my window of opportunity. Any higher and any lower, problems.
Just something to think about. Don't take the assumed doses for granted.
People who went all the way through long clinical trials said that milnacipran somehow reset thyroid and adrenal stuff, resulting in people who were always cold feeling normal instead. This happened months into treatment. The point is, milnacipran will have downstream effects in regulating things within you that are probably out of whack. Those things take a lot of time. And when they begin to change, as on the first dose, you will feel weird stuff. Add to that the withdrawals of the other meds, and yeah, you're gonna feel a bunch of weird stuff for a few weeks. No way around that.
Effexor doesn't have much impact on NE, so I doubt that was a factor in you feeling what you did when you tried it. It was almost totally serotonin. As well as whatever other unknown things effexor does that haven't been pinpointed yet.
poster:bleauberry
thread:947505
URL: http://www.dr-bob.org/babble/20100514/msgs/947544.html