Re: PDSP

Posted by linkadge on May 29, 2010, at 7:46:06

In reply to Re: Seroquel and AcH?, posted by SLS on May 28, 2010, at 22:53:39

According to a PDSP search (enter quetiapine in test ligand)
http://kidb.cwru.edu/pdsp.php
it says that m1 binding is around 100. These are in the same range as the results for the 5-ht2a receptor. The binding to other muscarinic receptors are lower 500+. The m1 receptor seems to be most implicated in depression however. M1 antagonists are endowed with antidepressant effects. I don't think the m1 receptors control things like mouth watering, sweating or global memory but I could be wrong.

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Seroquel and AcH? Bob 5/27/10
Re: Seroquel and AcH? SLS 5/28/10
Re: Seroquel and AcH? » SLS Bob 5/28/10
Re: Seroquel and AcH? SLS 5/28/10
Re: Seroquel and AcH? linkadge 5/28/10
Re: Seroquel and AcH? SLS 5/28/10
Re: Seroquel and AcH? SLS 5/28/10
Re: Seroquel and AcH? » SLS Bob 5/29/10
Re: Seroquel and AcH? » Bob SLS 5/29/10
Re: PDSP linkadge 5/29/10

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