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Re: Scott: Kindling? » Laney

Posted by SLS on June 10, 2010, at 11:17:38

In reply to Scott: Kindling?, posted by Laney on June 10, 2010, at 10:10:32

Hi Laney

> What exactly is it??
>
> Just curious. I've heard of it before.
>
> Laney

In epilepsy, kindling is a process by which the threshold for inducing a seizure becomes lower and lower with each successive seizure. In other words, it takes less and less to trigger a seizure. The kindling model has been proposed to explain why in bipolar disorder (and even unipolar depression), successive episodes become worse and worse, and are more easily triggered. Kindling also seems to explain the phenomenology of withdrawal from alcohol. I am thinking that it might also apply to withdrawal from benzodiazepines and SSRIs, as they might involve glutamatergic hyperexcitability.


- Scott


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