Posted by Conundrum on June 12, 2010, at 10:05:28
In reply to Re: Best med for anhedonia, lack of motivation, SCT? » former poster, posted by zonked on June 12, 2010, at 9:09:58
I've wondered about Parnate. Is it really good for anhedonia and "sluggish cognitive" tempo as the OP described it? Have there been success stories with Parnate curing anhedonia on this board?
Does Parnate decrease norepinephrine levels over time?
According to the not-so-accurate wikipedia, nardil decrease norepinephrine.
http://en.wikipedia.org/wiki/Phenelzine
"Notably, although phenelzine inhibits the breakdown of norepinephrine and epinephrine (which in concept should lead to increased levels of these two respective neurotransmitters), it actually typically significantly decreases their overall activity with time via a complex interaction with octopamine. This is the cause of the side effect of orthostatic hypotension commonly seen with phenelzine and the other MAOIs. Importantly, it has been demonstrated that the antidepressant effects of serotonin are actually mediated through norepinephrine.[9] As a result, this depletion of norepinephrine and epinephrine may significantly inhibit the full therapeutic potential of phenelzine and the other MAOIs. For this reason, augmenting with an adrenergic agent such as a norepinephrine reuptake inhibitor (NRI) or releasing agent (NRA) in conjunction may be desirable, though strict professional supervision is advised to minimize the risk of a potentially dangerous drug interaction such as hypertensive crisis."
Does Parnate do the same thing? Is this how Parnate makes people light headed? Although not cure, I've found glimmers of color with Pristiq that I never got with SSRIs, so I'm guessing norepinephrine reuptake inhibition could help with anhedonia. Some have mentioned Parnate+Nortriptyline, but I wonder what psychiatrist would actually prescribe that?
For the OP I think that maybe a NE reuptake inhibitor could help especially with motivation and concentration and might even make you feel pleasure. I don't really know since I've never been allowed to take a TCA. :( BTW wellbutrin isn't really a NE reuptake inhibitor from studies I've read.
Post-SSRI syndrome: iatrogenic anhedonia, memory and concentration problems, sexual dysfunction. [NOTE no sadness or anxiety]
Location:USA
Currently taking 25mg Lamictal.
poster:Conundrum
thread:950779
URL: http://www.dr-bob.org/babble/20100604/msgs/950791.html