Posted by ed_uk2010 on July 3, 2010, at 14:17:21
In reply to Re: Eh, contraindication not totally structure-related » tom2228, posted by SLS on July 3, 2010, at 13:27:47
> Without more information, it is difficult to judge risk.
I agree. There are a small number of reports of safe concomitant use of carbamazepine with phenelzine, tranylcypromine and moclobemide in the medical literature. As far as I can see, there are no reports of serious interactions such as serotonin syndrome.
My overall impression is that it's vital to be cautious when adding most other psych meds to MAOIs. Provided that there is a clear clinical justification for prescribing it, I don't think there is any reason to believe that carbamazepine should be contraindicated . Initial doses should obviously be low and careful monitoring should take place. The main problem with the carbamazepine + MAOI combination is probably medico-legal, due to the warning on the package insert. In my opinion, an initial test dose of 50mg carbamazepine would be prudent.
Ed
poster:ed_uk2010
thread:951790
URL: http://www.dr-bob.org/babble/20100628/msgs/953143.html